In a healthy, functioning brain, neurons do not come
into direct contact with blood. The vital oxygen and
nutrients the neurons need from the blood come to
the neurons across the thin walls of the cerebral
capillaries. The glia (nervous system cells that
support and protect neurons) form a blood-brain
barrier, an elaborate meshwork that surrounds
blood vessels and capillaries and regulates which
elements of the blood can pass through to the
neurons.
When an artery in the brain bursts, blood spews
out into the surrounding tissue and upsets not only
the blood supply but the delicate chemical balance
neurons require to function. This is called a
hemorrhagic stroke. Such strokes account for
approximately 20 percent of all strokes.
Hemorrhage can occur in several ways. One common
cause is a bleeding aneurysm, a weak or thin
spot on an artery wall. Over time, these weak spots
stretch or balloon out under high arterial pressure.
The thin walls of these ballooning aneurysms can
rupture and spill blood into the space surrounding
brain cells.
Hemorrhage also occurs when arterial walls break
open. Plaque-encrusted artery walls eventually lose
their elasticity and become brittle and thin, prone
to cracking. Hypertension, or high blood
pressure, increases the risk that a brittle
artery wall will give way and release blood into the
surrounding brain tissue.
A person with an arteriovenous malformation (AVM)
also has an increased risk of hemorrhagic stroke.
AVMs are a tangle of defective blood vessels and
capillaries within the brain that have thin walls
and can therefore rupture.
Bleeding from ruptured brain arteries can either
go into the substance of the brain or into the
various spaces surrounding the brain.
Intracerebral hemorrhage occurs when a vessel
within the brain leaks blood into the brain itself.
Subarachnoid hemorrhage is bleeding under the
meninges, or outer membranes, of the brain into the
thin fluid-filled space that surrounds the brain.
The subarachnoid space separates the arachnoid
membrane from the underlying pia mater membrane. It
contains a clear fluid (cerebrospinal fluid
or CSF) as well as the small blood vessels
that supply the outer surface of the brain. In a
subarachnoid hemorrhage, one of the small arteries
within the subarachnoid space bursts, flooding the
area with blood and contaminating the cerebrospinal
fluid. Since the CSF flows throughout the cranium,
within the spaces of the brain, subarachnoid
hemorrhage can lead to extensive damage throughout
the brain. In fact, subarachnoid hemorrhage is the
most deadly of all strokes.